Publications

  • Discovery of Novel and Orally Bioavailable Inhibitors of PI3 Kinase Based on Indazole Substituted Morpholino-Triazines. Sundeep Dugar, Frank P. Hollinger, Dinesh Mahajan, Somdutta Sen, Bilash Kuila, Reena Arora, Yogesh Pawar, Vaibhav Shinde, Mahesh Rahinj, Kamal K. Kapoor, Rahul Bhumkar, Santosh Rai, and Rakesh Kulkarni: DOI: 10.1021/acsmedchemlett.5b0032

  • Synthesis and evaluation of pyrrolotriazine based molecules as PI3 kinase inhibitors. Sundeep Dugar, Frank P. Hollinger, Bilash Kuila, Reena Arora, Somdutta Sen, Dinesh Mahajan: DOI: 10.1016/j.bmcl.2015.06.007

  • Preclinical activity of dual PI3K/mTOR inhibitor SPR965 in multiple myeloma. Jeremy T. Larsen, Vijay Ramakrishnan, Jessica Haug, Teresa Kimlinger, Somdutta Sen, Dinesh Mahajan, Sundeep Dugar, S. Vincent Rajkumar, Shaji K. Kumar.: DOI: 10.1158/1538-7445.AM2015-2653/ Cancer Res August 1, 2015 75; 2653

  • Nickel catalyzed [3+2] cycloaddition reaction of bis(methylenecyclopropane) with cyclic and acyclic dienophiles. Bilash Kuila, Dinesh Mahajan, Prabhpreet Singh, Gaurav Bhargava: Tetrahedron Letters, Volume 56, Issue 11, 11 March 2015, Pages 1307–1311 doi:10.1016/j.tetlet.2015.01.147

  • A Concise and Efficient Synthesis of Substituted Morpholines. Sundeep Dugar, Amit Sharma, Bilash Kuila, Dinesh Mahajan*, Sandeep Dwivedi, Vinayak Tripathi: Synthesis 2015; 47(05):DOI: 712-720 10.1055/s-0034-1379641

  • SPR965: an oral PI3K/ mTOR C1/C2 inhibitor for the treatment of solid tumors. Reena Arora, Bakul K. Dutta, Ravinder Goel, Frank P. Hollinger, Bilash Kulia, Dinesh Mahajan, Amal R. Mahapatra, Milind Sagar, Somdutta Sen, Amit Sharma, and Sundeep Dugar: Cancer Res October 1, 2014 74; 4515 DOI: 10.1158/1538-7445.AM2014-4515

  • Metal-free diastereoselective synthesis of diaza-bicyclo [3.2.0]heptan-7-one and its transformation to functionalized proline esters. Yogesh Kumara †, Bilash Kuila †, Dinesh Mahajan, Prabhpreet Singh, Balaram Mohapatra, Gaurav Bhargava: Tetrahedron Letters: Volume 55, Issue 17, 23 April 2014, Pages 2793–2795 DOI: 10.1016/j.tetlet.2014.02.105.

  • ATPS-61 new small molecules that kill hypoxically transformed glioma stem-like cells. Nagarekha Pasupuleti, Anthony Valenzuela, Yamini Manohar, Dinesh Mahajan, Sundeep Dugar, Jann Sarkaria and Fredric Gorin: Neuro Oncol (2015) 17 (suppl 5): v31. DOI: 10.1093/neuonc/nov204.61

  • International Entrepreneurship: Lessons from the Road, Sundeep Dugar*, Abhinav Dhandia:DOI: 10.1021/bk-2016-1219.ch013 , Publication Date:August 17, 2016

  • Impact of SPR064, a prodrug of paclitaxel, on ovarian cancer cell proliferation and tumor growth, K. Tucker*, A. Staley, Y. Fan, Y. Yin, W. Sun, X. Zhao, Y. Zhang, S. Dugar, C. Zhou, V.L. Bae-Jump: DOI: https://doi.org/10.1016/j.ygyno.2019.04.114

  • SPR 064, a highly soluble taxane, exhibits anti-tumorigenic effects in endometrial cancer, A. Staley*, K. Tucker, Y. Fan, X. Zhao, Y. Yin, Z. Fang, W. Sun, S. Sen, S. Dugar, Y. Zhang, C. Zhou, V.L. Bae-Jump: DOI: https://doi.org/10.1016/j.ygyno.2019.04.116

Patents

Sphaera Pharma has filed over 19 patents in last 10 years. Most of the patents have either been granted or are in late stage prosecution process in various jurisdictions. Few of the patents are at the early stage of prosecution and have entered national phases recently